Chiefs vs. 49ers Prediction: Odds, Expert Picks, QB Matchup, Injury Report, Betting Trends and Stats

The Kansas City Chiefs face the San Francisco 49ers this Sunday at 4:25 p.m. ET at Levi’s Stadium. Both teams couldn’t have started the season differently. The Chiefs are 5-0 while the 49ers are 3-3.

Despite the differences in their records, the two teams share an obvious similarity. Both are plagued by injuries. The Chiefs have already lost Isiah Pacheco and Rashee Rice to IR and WR Hollywood Brown has yet to take the field.

The most serious injury the 49ers have dealt with so far this season comes from last year’s Offensive Player of the Year, Christian McCaffery.

These two teams last met in the Super Bowl in 2020, where the Chiefs emerged victorious. In the past, this matchup has been closely contested, with the Chiefs holding a 6-5 edge over the 49ers.

NBC Sports will provide you with the latest information and analysis, including how to tune in, DraftKings odds, player news and updates, as well as expert predictions and best bets for the game.

Listen to the Bet the Edge podcast As hosts, Jay Croucher and Drew Dinsick provide listeners with sharp, actionable insights, market analysis and statistical data to help bettors gain more information before placing their bets.

Game details and how to watch Kansas City Chiefs @ San Francisco 49ers live on Sunday afternoon

· Date: Sunday, October 20, 2024
· Time: 4:25 p.m. ET
· Website: Levi’s Stadium
· City: Santa Clara, California
· TV/Streaming: FOX

Want to check out the other games on the? NFL schedule this week? We’ll provide you with all the matchup, venue, game time and TV/streaming information here on NBC Sports so you don’t miss any of the action!

Latest odds for Kansas City Chiefs @ San Francisco 49ers

The latest Saturday morning odds courtesy of DraftKings:

· Money line: Kansas City Chiefs (+105), San Francisco 49ers (-125)
· Spread: 49ers -2
· In total: 47

Given the Chiefs’ injuries, the line was initially intended as a pick’em but has worked out in the 49ers’ favor.

Be sure to check out DraftKings for the latest odds and player props for every match this week!

NBC Sports Bet Best Bets

NBC sports betting analyst Brad Thomas (@MrBradThomas) has his eye on the 49ers -2:
“The 49ers have the advantage of playing this game at home against a struggling Chiefs team. With the Chiefs coming into this game 5-0, this is a great sell for sports bettors.”

Kansas City Chiefs @ San Francisco 49ers team stats, betting trends

· The Chiefs have played 15 of their last 18 games as an away wing.
· The 49ers are 3-7 against the spread in their last 10 games.
· The Chiefs have won their last five games as underdogs.
· The 49ers are 12-6 in their last 18 games.

Kansas City Chiefs @ San Francisco 49ers quarterback matchup

· Bosses: Patrick Mahomes has thrown for 1,2355 yards, 6 TDs and 6 INTs.
· 49ers: Brock Purdy has thrown for 1,629 yards, 9 TDs and 4 INTs.

Kansas City and San Francisco player news and injuries

Bosses:
o WR JuJu Smith-Schuster (hamstring) is questionable
o WR Hollywood Brown (shoulder) is seen on IR
o WR Rashee Rice (knee) is on the IR
o RB Isiah Pacheco (fibula) is on IR

49ers:
o WR Ricky Pearsall (chest) is on NF-IR
o K Matthew Right (shoulder) is questionable
o WR Deebo Samuel Sr. (calf) is questionable
o RB Jordan Mason (shoulder) is questionable
o Christian McCaffery (calf/Achilles) is on IR

Rotoworld still provides you with the latest information NFL betting information and tools with match predictions, player props, futures and trends!

Expert Tips and Predictions for Kansas City @ San Francisco

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Our model calculates predictions for every moneyline, spread and over/under bet for every game on the NFL calendar based on data points such as past performance, player matchups and weather forecasts.

Once the model is finished running, we place its projection next to the latest betting lines for the game to determine a relative confidence level for each bet.

Here are the best bets our model predicts for the Chiefs @ 49ers:

· Money line: NBC Sports is staying away from a game on the money line
· Spread: NBC Sports leans toward using the Chiefs against the spread
· Game total: NBC Sports is leaning slightly towards a game with the overall score OVER 47.5.

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