Thursday Night Football odds, prediction, spread, line: 49ers vs. Seahawks picks from the NFL expert with a 23-5 record

The Seattle Seahawks (3-2) host the San Francisco 49ers (2-3) in a Thursday night football showdown to begin the NFL’s Week 6 schedule. The 49ers are looking to get back to winning ways after coming up short last week when the Arizona Cardinals beat San Francisco 24-23 as 7.5-point underdogs. Meanwhile, the Seahawks lost at home to the New York Giants 29-20. The Giants entered the game as 6.5 point underdogs.

Kickoff at Lumen Field in Seattle, Washington is scheduled for 8:15 p.m. ET. San Francisco is a 3.5-point favorite in the latest 49ers vs. Seahawks odds from SportsLine Consensus, while the over/under for total points is at 49.5, up 2.5 from the opener. The Niners are -187 moneyline favorites while the Seahawks are +157 underdogs. Before you make your pick between the Seahawks and 49ers, be sure to check out the NFL predictions and betting tips from SportsLine expert Micah Roberts, who is a master at picking San Francisco.

Micah Roberts has been in the Las Vegas sports betting industry for over 20 years, including 13 years as book director at Station Casinos. Roberts has a strong sense of the pulse of the 49ers. In fact, he has an astounding record of 23-5 (+1750) in his last 28 picks in games involving San Francisco. Anyone who follows is way up there.

Now, Roberts has focused on the 49ers vs. Seahawks game and just revealed his coveted NFL picks and predictions. You can head over to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines on spread, moneyline and over/under for Seahawks vs. 49ers:

• 49ers vs. Seahawks distribution: San Francisco -3.5
• 49ers vs. Seahawks over/under: 49.5 points
• 49ers vs. Seahawks Money Line: San Francisco -187, Seattle +157
• SF: San Francisco is 2-3, both straight and against the spread
• SEA: Seattle is 1-3-1 against the spread in 2024
• 49ers vs. Seahawks picks: See picks at SportsLine

Why the 49ers can cover

The 49ers have one of the best offensive units in the NFL. After five games, San Francisco ranks second in total offense (407.4), fourth in passing offense (263.4) and eighth in rushing offense (144). Quarterback Brock Purdy ranks fourth in the NFL in passing yards (1,374) and seventh in QBR (66) with six passing scores. On September 22 against the Rams, he went 22 of 30 for 292 yards and three passes.

Running back Jordan Mason is a physical and demanding ball carrier. He is first in the NFL in carries (105) and second in rushing yards (536) with three rushing touchdowns. Mason has rushed for more than 100 yards three times this season. Find out who you can support at SportsLine.

Why the Seahawks can cover

The Seahawks rank seventh in the NFL in total offense (376.2) and third in passing offense (270.8). Quarterback Geno Smith regularly puts his team in a position to be successful offensively. The West Virginia product is first in the league with five passing touchdowns (1,466). He has passed for over 280 yards in four straight games.

Receiver DK Metcalf is a physical playmaker with the quickness to run right past defenders. It’s difficult for Metcalf to bring him down while at the same time extending the field with ease. The 26-year-old ranks 10th in the league in receptions (28) and fourth in the league in receiving yards (421) with two scores and 15 yards per catch. The former Ole Miss star has three games with more than 100 receiving yards. Find out who you can support at SportsLine.

How to choose between 49ers and Seahawks

Roberts has analyzed 49ers vs. Seahawks from every possible angle, and while we can tell you he’s leaning over the total, he’s also discovered a critical X-factor that has him jumping over one side of the range. Find out what it is and which team you should support at SportsLine.

So who wins the Seahawks over the 49ers on Thursday Night Football and what key X-factor ensures one side of the spread gets hit hard? Visit SportsLine now to see which side of the Seahawks vs. 49ers is further down, all from the expert who is 23-5 on picks involving San Francisco, and find out.