49ers vs Seahawks prediction: odds, expert picks, QB matchup, injury updates, betting trends and stats

There’s an NFC West showdown with 1 on Thursday Night Football this week^st The spot is up for grabs when the San Francisco 49ers (2-3) travel to Lumen Field to take on the Seattle Seahawks (3-2). Each team limps into the match after losses in Week 5. Seattle lost at home to the Giants despite scoring on a 102-yard fumble return, and the Niners lost to the Cardinals 14-0 in the second half of their game at Levi’s Stadium.

Due to injuries, inconsistent play and especially poor 2nd^nd At halftime, the 49ers (+110) are no longer the overwhelming favorites to win the division. They’re still considered favorites to win the NFC (+350) and are among the favorites to win the Super Bowl (+800), but even those odds have fallen due to San Francisco’s uneven start.

Seattle started the season 3-0 and new head coach Mike Macdonald was praised for quickly rebuilding Seattle’s defense. Lost in the hype were the teams and quarterbacks the Seahawks played in the first three games, namely Bo Nix and the Broncos, Jacoby Brissett and the Patriots, and Skylar Thompson and the Dolphins. The celebration in Seattle is somewhat muted after losses to the Lions and Giants in the last two weeks.

Can the 49ers make it 4th in a row against the Seahawks? Let’s dive into the matchup and find a sweat or two.

NBC Sports has all the up-to-date information and analysis you need, including tip-off information, DraftKings odds, player news and updates, and of course our predictions and best bets for the game from our team of experts.

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Game details and how to watch 49ers @ Seahawks

• Date: Thursday, October 10, 2024
• Time: 8:15 p.m. EST
• Location: Lumen Field
• City: Seattle, WA
• TV/Streaming: Amazon PV

Want to check out the other games on the? NFL schedule this week? We’ll provide you with all the matchup, venue, game time and TV/streaming information here on NBC Sports so you don’t miss any of the action!

49ers @ Seahawks odds

Monday’s latest odds courtesy of DraftKings:

• Money line: San Francisco 49ers (-166), Seattle Seahawks (+140)
• Spread: 49ers -3
• In total: 47.5

This line is right where it started, with the 49ers leading by 3 points on the road. The total rose 0.5 points north to 47.5. Watch this space as injury news develops throughout the week.

NBC Sports Bet Best Bets

NBC sports betting analyst Vaughn Dalzell (@VmoneySports) likes to cover the 49ers on the road:
“That line should probably be more in the 4.5 to 5.5 range in my opinion. I think the Niners are clearly a better team than the Seahawks and despite all the injuries they are starting to overcome them and we finally had the big breakout game from Brandon Aiyuk that a lot of people had been waiting for.”
NBC Sports analyst Drew Dinsick (@whale_capper) has as much interest in Seattle as anyone, but even he has his limits when it comes to the Seahawks:
“My fair value here was 3.5…If you want the 3, you should act quickly.”

49ers @ Seahawks Team stats, betting trends

• San Francisco is playing its 6th^Th game in the last 31 days.
• The OVER has won two of the last three meetings with these clubs.
• San Francisco’s offense ranks 8th in EPA per play.
• Geno Smith rushed for a career-high 74 yards against the Giants last week.
• The Seahawks are 1-3-1 ATS and 4-1 OVER in 5 games this season.
• The 49ers are 2-3 ATS and 3-2 OVER in five games this season.

Quarterback matchup for 49ers @ Seahawks

• San Francisco: Brock Purdy – 2nd place^nd In the NFL, air yards are completed per attempt. He enjoys the 5th^Th Highest success rate per dropback in the league.
• Seattle: Geno Smith – Completed 28 of 40 passes with 1 TD for 284 yards against the Giants last weekend. Since Week 1, Smith has NOT thrown for fewer than 284 yards this season.

49ers @ Seahawks injury updates

• 49ers WR Chris Conley (oblique) is day-to-day and questionable for Thursday’s game.
• 49ers LB Demetrius Flannigan-Fowles (calf) is not expected to play Thursday night.
• 49ers DE Yetur Gross-Matos (knee surgery) was placed on IR late last week and is OUR for Thursday’s game.
• Seattle DT Byron Murphy was ruled out for Thursday’s game.

· Seattle CB Riq Woolen (ankle) is questionable for this week’s game.

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