Cardinals vs. 49ers Prediction: Odds, Expert Picks, QB Matchup, Injury Update, Betting Trends and Stats

No question, the 49ers (2-2) came out of the gate a little slower than expected. Sure, injuries played a role. With names like McCaffrey, Samuel and Kittle out, there was little chance the offense would be as efficient and effective. With bodies slower to return on that side of the ball, there is optimism in Niners’ Nation that the offense will find its way. However, it is the defense that remains a concern. Fred Warner’s injury impacted the entire defense. In their three games before last week’s affair against the beatless Patriots, the 49ers gave up 6.1 yards per play to the Jets, Vikings and Rams.

Their opponent on Sunday may not play much defense themselves, but their offense was impressive at times. Kyler Murray and the Arizona Cardinals (1-3) have been inconsistent and are struggling on offense, but they have weapons in addition to Murray. Like their quarterback, the Cards’ skill position players led by Marvin Harrison Jr., James Conner and Michael Wilson have shown they can put up numbers. In the first two weeks of the season, Arizona scored 69 points. However, they have scored 27 points in the last two weeks. This inconsistency coupled with a porous defense is why the Cardinals are living in the cellar in the NFC West.

Let’s dive into this match, take a look at the numbers and see if we can find a few sweats.

NBC Sports has all the up-to-date information and analysis you need, including tip-off information, DraftKings odds, player news and updates, and of course our predictions and best bets for the game from our team of experts.

Listen to the Bet the Edge podcast As hosts, Jay Croucher and Drew Dinsick provide listeners with sharp, actionable insights, market analysis and statistical data to help bettors gain more information before placing their bets.

Game details and how to watch Cardinals vs. 49ers

• Date: Sunday, October 6, 2024
• Time: 4:05 p.m. EST
• Location: Levi’s Stadium
• City: Santa Clara, CA
• TV/Streaming: FOX

Want to check out the other games on the? NFL schedule this week? We’ll provide you with all the matchup, venue, game time and TV/streaming information here on NBC Sports so you don’t miss any of the action!

Cardinals vs. 49ers odds

Thursday’s latest odds courtesy of DraftKings:

• Money line: Arizona Cardinals (+280), San Francisco 49ers (-355)
• Spread: 49ers -7.5
• In total: 50

In fact, last season, that line was San Francisco -9.5. At the start of the season the number dropped to -7.5 and has essentially remained there. The total was originally 49. The Sharps are expecting offense in this game, which explains the total going up by 1 point.

NBC Sports Bet Best Bets

NBC sports betting analyst Vaughn Dalzell (@VmoneySports) gets creative on this play.
“The total is a little high for me, so I’m sticking with a team here that paid me last week and might be my best choice this week.” The Niners -7. They have developed well and also get Deebo Samuel and Brandon Aiyuk back. These guys just keep getting better as the season goes on. Brock Purdy MVP talks are starting to pick up steam.”

Cardinals vs. 49ers Team stats, betting trends

• San Francisco has a record of 18-7 in the last 25 meetings between these teams.
• San Francisco has won its last four straight games against the Cardinals by an average of 22 points.
• Kyler Murray was sacked four times against Washington last week.
• 49ers RB1 Jordan Mason has rushed for more than 100 yards in three of four games this season
• Cards’ rookie WR Marvin Harrison Jr. has 243 receiving yards and 4 touchdowns

Cardinals vs. 49ers quarterback matchup

• Arizona: Kyler Murray – threw for just 142 yards in last week’s loss to Washington. This season he completed 69.4% of his passes with 6 TDs and 1 INT.
• San Francisco: Brock Purdy – beat the Patriots last week but was just 15-27 for 282 yards with 1 TD and 1 INT. Nice day of running, but well below his average completion rate.

Cardinals vs. 49ers injury updates

• Arizona K Matt Prater (knee) did not practice on Wednesday and is questionable for Sunday’s game.
• Arizona RT Kelvin Beachum (unknown) is questionable for Sunday’s game.
• Arizona TE Trey McBride (concussion) was limited in practice on Wednesday and is questionable for Sunday’s game.
• San Francisco SS Talanoa Hufanga (ankle) was limited in practice on Wednesday and is questionable for Sunday’s game.
• San Francisco LB Fred Warner (ankle) did not practice on Wednesday and is questionable for Sunday’s game.
• San Francisco TE George Kittle (ribs) did not practice on Wednesday and is questionable for Sunday’s game.

Rotoworld provides you with the latest information NFL betting information and tools with match predictions, player props, futures and trends!

Follow our experts on social media to stay up to date with the latest staff content: