New Orleans Saints vs. Kansas City Chiefs Prediction, Odds, Spread, Injuries, Trends for NFL Week 5

The Chiefs and Vikings enter Week 5 as the only undefeated teams. The Saints will look to hand the Chiefs their first loss since Week 15 in 2023 at Arrowhead for Monday Night Football.

The Saints lead the league with 31.4 offensive points per game, while the Chiefs average 23.

Defensively, both teams have top units, with the Chiefs allowing just 18 points per game while the Saints allowed 17.5 points.

Who will emerge victorious in this non-conference matchup? Let’s break it down.

Spread

Money line

In total

Saints injury report

Chiefs injury report

Saint RB Alvin Kamara

Kamara was the focal point of this Saints offense. His five rushing touchdowns tie for the NFL high with Derrick Henry and Kyren Williams — and he would have at least two more if Taysom Hill wasn’t a goal-line vulture. Hill will likely miss this game, so we should expect Kamara to score. Kamara will also be a weapon for Carr in the short passing game.

But how efficient will Kamara be on the ground compared to a Chiefs defense that has allowed running backs just 56 rushing yards per game this season?

Chiefs TE Travis Kelce

Kelce appears to have slowed down a bit this season, but he was able to successfully step up his game after Rice left the game in Week 4. Kelce caught seven of his nine targets for 98 yards and led the team in all receiving categories. The matchup is favorable against the Saints, who have allowed the sixth-most receiving yards to opposing tight ends this season and an average of 9.43 yards per target.

The Chiefs are without Isiah Pacheco and Rashee Rice, leaving only Travis Kelce as the biggest threat. Xavier Worthy should see more targets and have some special moments as well, but overall the Saints should be able to put together a competent defensive game plan. New Orleans has only allowed opposing runners 84 yards per game this year, so Mahomes will need to find some success through the air. The Saints have allowed 1,009 passing yards this season but only one passing touchdown.

The Saints have been explosive this season, with Alvin Kamara being a real threat in the run game and creating play opportunities for Derek Carr and his receivers. It’s not an easy matchup on the ground against the Chiefs, but Kansas City has allowed opposing passers the 10th-most passing yards and five passing touchdowns this season. Klint Kubiak got the best out of his players and I expect them to give their best this week with extra rest.

The Chiefs may win this game, but the Saints will at least keep it close. Get the points for the underdogs, who have the more explosive offense and better defense.

Selection: Saints +5.5

The game odds are updated regularly and are subject to change.

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