Positive responses to the sexual encounter questionnaire

Using MED3000 topical gel for erectile dysfunction appears to provide benefits for both men and their partners, according to data from the Sexual Encounter Profile (SEP) presented at the Sexual Medicine Society of North America 2024 Fall Scientific Meeting in Scottsdale, Arizona , were presented.¹

“MED3000 is an FDA-approved, over-the-counter topical gel that is applied to the glans penis by the patient or partner,” said the authors, led by Faysal A. Yafi, MD, FRCSC, associate professor of urology. Director of Newport Beach Urology, Director of Men’s Health and Director of Men’s Health and Reconstructive Urology at the University of California, Irvine.

Previously reported data from two Phase 3 clinical trials indicated the safety and effectiveness of MED3000. Researchers found that approximately 60% of patients in the two studies experienced clinically meaningful improvements in International Index of Erectile Function-Erectile Function (IIEF-EF) domain scores. The gel was also found to be safe and poses a low risk of local or systemic events.²

For the current study, researchers sought to assess MED3000 responses in men and their partners using the SEP. They conducted a 12-week multicenter study with patients from Poland, Czech Republic, Slovakia, Hungary, Georgia, Bulgaria, Latvia, Russia and Ukraine. Instructions were given to use MED3000 immediately before sexual intercourse. Participants “were required to make at least four attempts at intercourse during each of the three four-week periods during treatment (weeks 1-4, 5-8, and 9-12),” the authors write. Both patients and partners were asked to perform SEP after each sexual intercourse attempt. Researchers calculated the average percentage of patients and partners who answered “yes” at baseline. They also determined means and changes from baseline for each 4-week period and for the entire study.

The SEP questions were as follows:

1. Were you/was your partner able to achieve at least a certain erection (some penis enlargement)?

2. Were you/your partner able to insert your/his penis into her/her vagina?

3. Did your (partner’s) erection last long enough to allow successful intercourse?

4. Were you satisfied with the hardness of your (partner’s) erection?

5. Overall, were you satisfied with the sexual experience?

A total of 250 patients were included in the study, of which 249 were white and 1 was Asian. The mean patient age ± standard deviation was 46.8 ± 12.5 years. The duration of erectile dysfunction was 27.5 ± 36.5 months. The degree of erectile dysfunction was mild, moderate, or severe in 59.2%, 28.0%, and 12.8% of patients, respectively. Baseline IIEF-EF was 16.6 ± 4.7. All but one partner was white, one was Asian, and the mean age was 43.4 ± 11.9 years.

After using MED3000, researchers reported significant improvements in all 5 SEP questions in both patients and partners over the course of 12 weeks.

“Improvements from baseline for all SEP questions in both subjects and their partners reached statistical significance after 4 weeks (P

REFERENCES

1. Yafi F, Brock G, Honig S, Fisher M. Topical administration of MED3000 gel significantly improves all aspects of the sexual encounter profile for both men and their partners. Presented at: Sexual Medicine Society of North America Fall Scientific Meeting 2024. 17th-20th October 2024. Scottsdale, Arizona. Summary 223

2. Hellstrom WJG, Brock GB, Burnett AL, Holland TJ, James KW. Efficacy and safety of MED3000, a novel topical therapy for the treatment of erectile dysfunction. Presented at the 2024 Annual Meeting of the American Urological Association. May 3-6, 2024. San Antonio, Texas.